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Synthesis of Spiroquinolines through a One‐Pot Multicatalytic and Multicomponent Cascade Reaction
Author(s) -
Barluenga José,
Mendoza Abraham,
Rodríguez Félix,
Fañanás Francisco J.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802582
Subject(s) - aldehyde , aniline , quinoline , cascade , catalysis , platinum , chemistry , combinatorial chemistry , coupling reaction , cascade reaction , component (thermodynamics) , organic chemistry , physics , chromatography , thermodynamics
Three's company : Functionalized spirocyclic quinoline derivatives are easily synthesized in a one‐pot three‐component coupling process involving the reaction of alkynol, aldehyde, and aniline derivatives (see scheme). The process is carried out in the presence of catalytic amounts of a platinum(II) complex and a protic acid.