Synthesis of Spiroquinolines through a One‐Pot Multicatalytic and Multicomponent Cascade Reaction | Zendy

Barluenga José | Zendy; Mendoza Abraham | Zendy; Rodríguez Félix | Zendy; Fañanás Francisco J. | Zendy

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Synthesis of Spiroquinolines through a One‐Pot Multicatalytic and Multicomponent Cascade Reaction

Author(s) -

Barluenga José,

Mendoza Abraham,

Rodríguez Félix,

Fañanás Francisco J.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200802582

Subject(s) - aldehyde , aniline , quinoline , cascade , catalysis , platinum , chemistry , combinatorial chemistry , coupling reaction , cascade reaction , component (thermodynamics) , organic chemistry , physics , chromatography , thermodynamics

Three's company : Functionalized spirocyclic quinoline derivatives are easily synthesized in a one‐pot three‐component coupling process involving the reaction of alkynol, aldehyde, and aniline derivatives (see scheme). The process is carried out in the presence of catalytic amounts of a platinum(II) complex and a protic acid.

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