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Divergent Titanium‐Mediated Allylations with Modulation by Nickel or Palladium
Author(s) -
Campaña Araceli G.,
Bazdi Btissam,
Fuentes Noelia,
Robles Rafael,
Cuerva Juan M.,
Oltra J. Enrique,
Porcel Susana,
Echavarren Antonio M.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802520
Subject(s) - palladium , stereoselectivity , nickel , chemistry , titanium , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
Palladium and nickel are used in conjunction with titanocene(III) complexes to perform selective allylations of carbonyl compounds and alkenes, respectively. Pd/Ti‐catalyzed allylation of ketones proceeds diastereoselectively under mild conditions, whereas Ni/Ti‐promoted cyclizations provide polyalkyl‐substituted carbo‐ and heterocycles with excellent control over regio‐ and stereoselectivity.