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Self‐Immolative Polymers
Author(s) -
Wang Wenxin,
Alexander Cameron
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802474
Subject(s) - polymer , cleavage (geology) , fluorescence , fragmentation (computing) , chemistry , biophysics , enzyme , nanotechnology , materials science , biochemistry , computer science , biology , organic chemistry , physics , operating system , quantum mechanics , fracture (geology) , composite material
This message will self‐destruct! Polymers that can be triggered to disassemble in a sequential fashion following a single triggering event were described recently. The amplification effect after cleavage of an end group by an enzyme leads to the spontaneous fragmentation of the polymer and the release of fluorescent reporters. The significance of these systems in terms of enzyme detection and drug release is discussed.