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Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery
Author(s) -
Kim Jaeyun,
Kim Hoe Suk,
Lee Nohyun,
Kim Taeho,
Kim Hyoungsu,
Yu Taekyung,
Song In Chan,
Moon Woo Kyung,
Hyeon Taeghwan
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802469
Subject(s) - mesoporous silica , nanoparticle , nanocrystal , ethylene glycol , nanotechnology , materials science , drug delivery , fluorescence , magnetite , magnetic nanoparticles , shell (structure) , magnetic resonance imaging , mesoporous material , chemistry , organic chemistry , optics , medicine , physics , metallurgy , composite material , radiology , catalysis
Magnetic, fluorescent core–shell nanoparticles consist of a single Fe 3 O 4 nanocrystal core and a dye‐doped mesoporous silica shell with a poly(ethylene glycol) coating (see picture of TEM images and schematic depictions). These nanoparticles can be used as magnetic resonance and fluorescence imaging agents, and as drug delivery vehicles, thus making them novel candidates for simultaneous cancer diagnosis and therapy.