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Attrition‐Enhanced Deracemization of an Amino Acid Derivative That Forms an Epitaxial Racemic Conglomerate
Author(s) -
Kaptein Bernard,
Noorduin Wim L.,
Meekes Hugo,
van Enckevort Willem J. P.,
Kellogg Richard M.,
Vlieg Elias
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802468
Subject(s) - racemization , ostwald ripening , epitaxy , grinding , derivative (finance) , crystal (programming language) , enantiomer , chirality (physics) , materials science , yield (engineering) , chemistry , chemical engineering , organic chemistry , crystallography , nanotechnology , computer science , composite material , chiral symmetry breaking , physics , layer (electronics) , quantum mechanics , quark , financial economics , nambu–jona lasinio model , economics , programming language , engineering
Just bead it! Despite the complication of enantiomeric epitaxial behavior, a derivative of phenylalanine was completely resolved (see picture). Racemization takes place by abrasively grinding crystals of the compound in a saturated solution. By studying the influence of different crystal sizes, it was found that Ostwald ripening plays an important role in this process. DBU=1,8‐diazabicyclo[5.4.0]undec‐7‐ene.