Attrition‐Enhanced Deracemization of an Amino Acid Derivative That Forms an Epitaxial Racemic Conglomerate | Zendy

Kaptein Bernard | Zendy; Noorduin Wim L. | Zendy; Meekes Hugo | Zendy; van Enckevort Willem J. P. | Zendy; Kellogg Richard M. | Zendy; Vlieg Elias | Zendy

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Attrition‐Enhanced Deracemization of an Amino Acid Derivative That Forms an Epitaxial Racemic Conglomerate

Author(s) -

Kaptein Bernard,

Noorduin Wim L.,

Meekes Hugo,

van Enckevort Willem J. P.,

Kellogg Richard M.,

Vlieg Elias

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200802468

Subject(s) - racemization , ostwald ripening , epitaxy , grinding , derivative (finance) , crystal (programming language) , enantiomer , chirality (physics) , materials science , yield (engineering) , chemistry , chemical engineering , organic chemistry , crystallography , nanotechnology , computer science , composite material , chiral symmetry breaking , physics , layer (electronics) , quantum mechanics , quark , financial economics , nambu–jona lasinio model , economics , programming language , engineering

Just bead it! Despite the complication of enantiomeric epitaxial behavior, a derivative of phenylalanine was completely resolved (see picture). Racemization takes place by abrasively grinding crystals of the compound in a saturated solution. By studying the influence of different crystal sizes, it was found that Ostwald ripening plays an important role in this process. DBU=1,8‐diazabicyclo[5.4.0]undec‐7‐ene.

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