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New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan
Author(s) -
Flecks Silvana,
Patallo Eugenio P.,
Zhu Xiaofeng,
Ernyei Aliz J.,
Seifert Gotthard,
Schneider Alexander,
Dong Changjiang,
Naismith James H.,
van Pée KarlHeinz
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802466
Subject(s) - library science , humanities , philosophy , chemistry , classics , art , computer science
It takes two : Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme).