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Interactions of Small Protected Peptides with Aminopyrazole Derivatives: The Efficiency of Blocking a β‐Sheet Model in the Gas Phase
Author(s) -
Fricke Holger,
Gerlach Andreas,
Unterberg Claus,
Wehner Mark,
Schrader Thomas,
Gerhards Markus
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802396
Subject(s) - gas phase , blocking (statistics) , yield (engineering) , chemistry , hydrogen bond , beta sheet , phase (matter) , mass spectrometry , combinatorial chemistry , peptide , materials science , organic chemistry , chromatography , molecule , biochemistry , computer science , metallurgy , computer network
Binding motifs of aminopyrazole derivatives with different peptides in the gas phase are investigated by using mass‐ and isomer‐selective IR/UV spectroscopy. The efficiency of blocking a β‐sheet model is determined by analyzing the number and strength of hydrogen bonds (see picture). The investigations yield information on intrinsic molecular properties of beginning aggregation behavior, as might also occur in misfolding diseases.