Premium
Organocatalytic Enantioselective Aminosulfenylation of α,β‐Unsaturated Aldehydes
Author(s) -
Zhao GuiLing,
Rios Ramon,
Vesely Jan,
Eriksson Lars,
Córdova Armando
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802335
Subject(s) - enantioselective synthesis , electrophile , domino , organocatalysis , chemistry , catalysis , organic chemistry , transformation (genetics) , combinatorial chemistry , biochemistry , gene
Domino theory : A simple, highly enantioselective organocatalytic aminosulfenylation of α,β‐unsaturated aldehydes affords orthogonally protected β‐amino‐α‐mercaptoaldehydes in high yields and 93 to >99 % ee (see scheme, Bn=benzyl). Notably, the catalytic transformation shows that it is possible to efficiently employ all components of an electrophile, which includes a nucleofuge, in organocatalytic domino reactions of enals.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom