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Ortho ‐TMS Benzaldehyde: An Effective Linchpin for Type II Anion Relay Chemistry (ARC)
Author(s) -
Smith Amos B.,
Kim WonSuk,
Wuest William M.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802301
Subject(s) - center (category theory) , chemistry , library science , computer science , crystallography
ARC de triomphe : Ortho ‐TMS benzaldehyde permits efficient multicomponent union of a variety of nucleophiles and electrophiles, including the first example of a Pd‐mediated ARC Type II process. A “proof‐of‐concept” synthetic sequence was designed and implemented for construction of a focused library of “natural product‐like” compounds (see scheme). ARC: anion relay chemistry.