Sustained Release of Drugs Dispersed in Polymer Nanoparticles | Zendy

Jacobson Gunilla B. | Zendy; Shinde Rajesh | Zendy; Contag Christopher H. | Zendy; Zare Richard N. | Zendy

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Sustained Release of Drugs Dispersed in Polymer Nanoparticles

Author(s) -

Jacobson Gunilla B.,

Shinde Rajesh,

Contag Christopher H.,

Zare Richard N.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200802260

Subject(s) - adenosine triphosphate , nanoparticle , biodegradable polymer , polymer , chemistry , in vivo , in vitro , supercritical fluid , adenosine diphosphate , controlled release , adenosine , lactic acid , biophysics , nanotechnology , biochemistry , materials science , organic chemistry , medicine , bacteria , platelet , platelet aggregation , immunology , microbiology and biotechnology , genetics , biology

Please release me : Supercritical carbon dioxide was used as an antisolvent for the formation of nanoparticles that contain luciferin, a bioactive therapeutic, dispersed in poly(lactic acid) (PLA), a biodegradable polymer. These nanoparticles undergo slow and sustained drug release, which can be monitored by bioluminescence both in vitro and in vivo (see picture; ATP=adenosine triphosphate; ADP=adenosine diphosphate; Pi=inorganic phosphate).

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