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Sustained Release of Drugs Dispersed in Polymer Nanoparticles
Author(s) -
Jacobson Gunilla B.,
Shinde Rajesh,
Contag Christopher H.,
Zare Richard N.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802260
Subject(s) - adenosine triphosphate , nanoparticle , biodegradable polymer , polymer , chemistry , in vivo , in vitro , supercritical fluid , adenosine diphosphate , controlled release , adenosine , lactic acid , biophysics , nanotechnology , biochemistry , materials science , organic chemistry , medicine , bacteria , platelet , platelet aggregation , immunology , microbiology and biotechnology , genetics , biology
Please release me : Supercritical carbon dioxide was used as an antisolvent for the formation of nanoparticles that contain luciferin, a bioactive therapeutic, dispersed in poly(lactic acid) (PLA), a biodegradable polymer. These nanoparticles undergo slow and sustained drug release, which can be monitored by bioluminescence both in vitro and in vivo (see picture; ATP=adenosine triphosphate; ADP=adenosine diphosphate; Pi=inorganic phosphate).