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Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor
Author(s) -
Vomasta Daniel,
Högner Christina,
Branda Neil R.,
König Burkhard
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802242
Subject(s) - photochromism , carbonic anhydrase , carbonic anhydrase ii , chemistry , biochemistry , enzyme , photochemistry
Photoswitchable : The activity of a dithienylethene‐based human carbonic anhydrase inhibitor (hCAI) can be regulated using light. Converting the flexible, ring‐open isomer of the photoswitch into the rigid, ring‐closed isomer using UV light reduces the inhibition and increases the activity of hCAI by 50‐fold. The inhibitor can be turned back on by using visible light, which has many advantages in biological applications.