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Synthesis of Indolines and Tetrahydroisoquinolines from Arylethylamines by Pd II ‐Catalyzed CH Activation Reactions
Author(s) -
Li JiaoJie,
Mei TianSheng,
Yu JinQuan
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802187
Subject(s) - chemistry , amination , catalysis , phenylalanine , tyrosine , tryptophan , halogenation , combinatorial chemistry , amino acid , stereochemistry , medicinal chemistry , organic chemistry , biochemistry
Hand in hand : A versatile CH activation route for the synthesis of indolines, tetrahydroquinolines, and tetrahydroisoquinolines from simple arylethylamines relies on a one‐pot iodination and amination reaction (see scheme, Tf=trifluoromethanesulfonyl). The natural amino acids phenylalanine, tyrosine, and tryptophan can be converted into various heterocycles by using this technology.