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Systems Chemistry on Ribozyme Self‐Construction: Evidence for Anabolic Autocatalysis in a Recombination Network
Author(s) -
Hayden Eric J.,
von Kiedrowski Günter,
Lehman Niles
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802177
Subject(s) - autocatalysis , ribozyme , anabolism , vs ribozyme , chemistry , rna world hypothesis , rna , hairpin ribozyme , biophysics , catalysis , computational biology , biochemistry , biology , gene
Humpty Dumpty, heal thyself : Four fragments of a catalytic RNA can autocatalytically self‐assemble back into a covalently contiguous ribozyme. This reaction network (see picture) demonstrates anabolic autocatalysis in which positive feedback occurs at multiple points.