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Fluorinating Cleavage of Solid Phase Linkers for Combinatorial Synthesis
Author(s) -
Wiehn Matthias S.,
Lindell Stephen D.,
Bräse Stefan
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802126
Subject(s) - linker , solid phase synthesis , cleavage (geology) , fluorine , combinatorial chemistry , chemistry , combinatorial synthesis , nanotechnology , computer science , organic chemistry , materials science , programming language , biochemistry , peptide , fracture (geology) , composite material
Multitasking : A new preparative route to fluorine‐containing compounds combines the advantages of solid‐phase synthesis with the incorporation of fluorine at the end of the synthetic route. A sulfur linker enables simultaneous fluorination of the target structures in the cleavage step. As it is stable under different reaction conditions, the linker has potential in the combinatorial synthesis of fluorinated drug structures.