Premium
Rapid Analysis of Organic Compounds by Proton‐Detected Heteronuclear Correlation NMR Spectroscopy with 40 kHz Magic‐Angle Spinning
Author(s) -
Zhou Donghua H.,
Rienstra Chad M.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802108
Subject(s) - heteronuclear molecule , magic angle spinning , proton , two dimensional nuclear magnetic resonance spectroscopy , spectral line , nuclear magnetic resonance , spinning , chemistry , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , spectroscopy , materials science , chromatography , physics , nuclear physics , polymer chemistry , astronomy , quantum mechanics
High‐sensitivity proton detection enabled acquisition of well‐resolved two‐dimensional spectra in only 30 minutes for less than 5 mg of organic compounds at natural abundance. Besides faster resonance assignment, rapid analysis of crystal polymorphism, molecular dynamics, and H‐bonding is possible. This method is applicable to both pure and dosage forms of solid pharmaceuticals, such as ibuprofen (see picture).