Synthetic Vaccines Consisting of Tumor‐Associated MUC1 Glycopeptide Antigens and a T‐Cell Epitope for the Induction of a Highly Specific Humoral Immune Response | Zendy

Westerlind Ulrika | Zendy; Hobel Alexandra | Zendy; Gaidzik Nikola | Zendy; Schmitt Edgar | Zendy; Kunz Horst | Zendy

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Synthetic Vaccines Consisting of Tumor‐Associated MUC1 Glycopeptide Antigens and a T‐Cell Epitope for the Induction of a Highly Specific Humoral Immune Response

Author(s) -

Westerlind Ulrika,

Hobel Alexandra,

Gaidzik Nikola,

Schmitt Edgar,

Kunz Horst

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200802102

Subject(s) - glycopeptide , epitope , immune system , muc1 , ovalbumin , antigen , mucin , immunology , immunotherapy , t cell , antibody , biology , microbiology and biotechnology , biochemistry , antibiotics

Selective response : The fully synthetic vaccine shown, which contains a glycopeptide antigen from the tumor‐associated mucin MUC1 and an immunostimulating T‐cell epitope from ovalbumin, induces a highly specific immune response in mice. The induced antibody reacts with the glycopeptides and analogues that carry additional tumor‐associated T N antigen monosaccharides in their sequence.

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