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Synthetic Vaccines Consisting of Tumor‐Associated MUC1 Glycopeptide Antigens and a T‐Cell Epitope for the Induction of a Highly Specific Humoral Immune Response
Author(s) -
Westerlind Ulrika,
Hobel Alexandra,
Gaidzik Nikola,
Schmitt Edgar,
Kunz Horst
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802102
Subject(s) - glycopeptide , epitope , immune system , muc1 , ovalbumin , antigen , mucin , immunology , immunotherapy , t cell , antibody , biology , microbiology and biotechnology , biochemistry , antibiotics
Selective response : The fully synthetic vaccine shown, which contains a glycopeptide antigen from the tumor‐associated mucin MUC1 and an immunostimulating T‐cell epitope from ovalbumin, induces a highly specific immune response in mice. The induced antibody reacts with the glycopeptides and analogues that carry additional tumor‐associated T N antigen monosaccharides in their sequence.