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Convergent Preparation of Enantiomerically Pure Polyalkylated Cyclopropane Derivatives
Author(s) -
Abramovitch Adi,
Fensterbank Louis,
Malacria Max,
Marek Ilan
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802093
Subject(s) - cyclopropane , diastereomer , lithium (medication) , chemistry , sulfoxide , organic chemistry , combinatorial chemistry , ring (chemistry) , medicine , endocrinology
Crossroads : Selective sulfoxide/lithium exchange reactions lead to the unique preparation of diastereo‐ and enantiomerically pure polyalkylated cyclopropanes (see scheme). This reaction allows the independent formation of both diastereoisomers from a common starting material.
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