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The Asymmetric Total Synthesis of (+)‐Cytotrienin A, an Ansamycin‐Type Anticancer Drug
Author(s) -
Hayashi Yujiro,
Shoji Mitsuru,
Ishikawa Hayato,
Yamaguchi Junichiro,
Tamura Tomohiro,
Imai Hiroki,
Nishigaya Yosuke,
Takabe Kenichi,
Kakeya Hideaki,
Osada Hiroyuki
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802079
Subject(s) - total synthesis , enantioselective synthesis , deoxygenation , chemistry , aldol reaction , ring closing metathesis , stereochemistry , metathesis , salt metathesis reaction , combinatorial chemistry , organic chemistry , polymerization , catalysis , polymer
A star‐studded lineup : (+)‐Cytotrienin A was the target of an asymmetric total synthesis featuring an enantioselective aldol reaction, α‐aminoxylation, deoxygenation, and a ring‐closing metathesis to form the 21‐membered macrolactam. This first total synthesis confirms the relative and absolute confguration of the molecule.