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Iron‐Catalyst‐Switched Selective Conjugate Addition of Grignard Reagents: α,β,γ,δ‐Unsaturated Amides as Versatile Templates for Asymmetric Three‐Component Coupling Processes
Author(s) -
Okada Satoshi,
Arayama Kyohei,
Murayama Ryuji,
Ishizuka Takumi,
Hara Keiichi,
Hirone Naoki,
Hata Takeshi,
Urabe Hirokazu
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801928
Subject(s) - template , conjugate , reagent , combinatorial chemistry , component (thermodynamics) , halide , amide , catalysis , chemistry , alkyl , coupling (piping) , organic chemistry , materials science , nanotechnology , physics , mathematics , metallurgy , thermodynamics , mathematical analysis
Diene for conjugate addition : Iron(II) chloride switches the reaction course of the three‐component coupling of a Grignard reagent, an alkyl halide, and a dienamide, thus making the amide a simple yet versatile chiral template.