Iron‐Catalyst‐Switched Selective Conjugate Addition of Grignard Reagents: α,β,γ,δ‐Unsaturated Amides as Versatile Templates for Asymmetric Three‐Component Coupling Processes | Zendy

Okada Satoshi | Zendy; Arayama Kyohei | Zendy; Murayama Ryuji | Zendy; Ishizuka Takumi | Zendy; Hara Keiichi | Zendy; Hirone Naoki | Zendy; Hata Takeshi | Zendy; Urabe Hirokazu | Zendy

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Iron‐Catalyst‐Switched Selective Conjugate Addition of Grignard Reagents: α,β,γ,δ‐Unsaturated Amides as Versatile Templates for Asymmetric Three‐Component Coupling Processes

Author(s) -

Okada Satoshi,

Arayama Kyohei,

Murayama Ryuji,

Ishizuka Takumi,

Hara Keiichi,

Hirone Naoki,

Hata Takeshi,

Urabe Hirokazu

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200801928

Subject(s) - template , conjugate , reagent , combinatorial chemistry , component (thermodynamics) , halide , amide , catalysis , chemistry , alkyl , coupling (piping) , organic chemistry , materials science , nanotechnology , physics , mathematics , metallurgy , thermodynamics , mathematical analysis

Diene for conjugate addition : Iron(II) chloride switches the reaction course of the three‐component coupling of a Grignard reagent, an alkyl halide, and a dienamide, thus making the amide a simple yet versatile chiral template.

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