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Synthesis of QS‐21‐Xylose: Establishment of the Immunopotentiating Activity of Synthetic QS‐21 Adjuvant with a Melanoma Vaccine
Author(s) -
Deng Kai,
Adams Michelle M.,
Damani Payal,
Livingston Philip O.,
Ragupathi Govind,
Gin David Y.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801885
Subject(s) - xylose , adjuvant , saponin , melanoma , residue (chemistry) , chemistry , vaccine adjuvant , medicine , biochemistry , immunology , cancer research , fermentation , pathology , alternative medicine
A helping hand : The adjuvant QS‐21‐xylose (see structure; the xylose residue is shown in red) was obtained in pure form by chemical synthesis. When combined with its synthetic apiose isomer to furnish synthetic QS‐21 (sQS‐21), the saponin combination was shown to aid the production of antibodies in mice when injected with a melanoma vaccine. The preparation of sQS‐21 provides access to pure, functional saponin adjuvants of defined composition.