Palladium‐Catalyzed Enantioselective Oxidation of Chiral Secondary Alcohols: Access to Both Enantiomeric Series | Zendy

Ebner David C. | Zendy; Trend Raissa M. | Zendy; Genet Cédric | Zendy; McGrath Matthew J. | Zendy; O'Brien Peter | Zendy; Stoltz Brian M. | Zendy

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Palladium‐Catalyzed Enantioselective Oxidation of Chiral Secondary Alcohols: Access to Both Enantiomeric Series

Author(s) -

Ebner David C.,

Trend Raissa M.,

Genet Cédric,

McGrath Matthew J.,

O'Brien Peter,

Stoltz Brian M.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200801865

Subject(s) - kinetic resolution , enantiomer , enantioselective synthesis , catalysis , palladium , chemistry , selectivity , alcohol oxidation , diamine , combinatorial chemistry , enantiomeric excess , organic chemistry

Rapid resolution : A new catalyst system for the oxidative kinetic resolution of secondary alcohols leads to dramatic rate increases. This system allows the use of a diamine to provide access to either enantiomer of a range of alcohols with good selectivity factors (see scheme). This method has been applied to the formal total synthesis of (−)‐amurensinine.

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