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Complete Deracemization by Attrition‐Enhanced Ostwald Ripening Elucidated
Author(s) -
Noorduin Wim L.,
Meekes Hugo,
van Enckevort Willem J. P.,
Millemaggi Alessia,
Leeman Michel,
Kaptein Bernard,
Kellogg Richard M.,
Vlieg Elias
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801846
Subject(s) - ostwald ripening , attrition , grinding , chirality (physics) , slurry , ripening , computer science , process engineering , chemistry , nanotechnology , food science , materials science , thermodynamics , physics , engineering , metallurgy , medicine , chiral symmetry breaking , dentistry , quantum mechanics , quark , nambu–jona lasinio model
Shaken and stirred : The emergence of single chirality in the solid state during grinding of a slurry has been kinetically studied for a phenylglycine amide (see scheme). The insight obtained into the underlying process of attrition‐enhanced Ostwald ripening enables the definition of suitable conditions to increase the deracemization rate drastically.