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Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery
Author(s) -
Park JiHo,
von Maltzahn Geoffrey,
Ruoslahti Erkki,
Bhatia Sangeeta N.,
Sailor Michael J.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801810
Subject(s) - ethylene glycol , micelle , drug delivery , nanoparticle , peg ratio , nanotechnology , doxorubicin , drug , materials science , chemistry , targeted drug delivery , aqueous solution , organic chemistry , pharmacology , medicine , surgery , finance , chemotherapy , economics
Multimodal nanoassemblies that contain magnetic nanoparticles, quantum dots, and the anticancer drug doxorubicin within a single PEG–phospholipid micelle were prepared (see scheme; PEG=poly(ethylene glycol)). When equipped with the targeting peptide F3, these nanostructures enable simultaneous targeted drug delivery and dual‐mode imaging of tumor tissues by near‐infrared fluorescence and NMR spectroscopy.