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Synthesis of Marine Alkaloids from the Oroidin Family
Author(s) -
Arndt HansDieter,
Riedrich Matthias
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801793
Subject(s) - alkene , total synthesis , alkaloid , stereochemistry , chemistry , combinatorial chemistry , organic chemistry , catalysis
Oxidation with a difference : The complexity of the oroidin alkaloid family of marine natural products is generated biosynthetically from one simple alkene precursor, but has left the synthetic community with problems. The first total synthesis of the tetracyclic axinellamines (see structure) was recently completed. Key to the success was the chemoselective oxidative functionalization of imidazol(in)e rings (green).