Premium
Cobalt‐Catalyzed [2+2] Cycloaddition
Author(s) -
Treutwein Jonas,
Hilt Gerhard
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801778
Subject(s) - cyclobutene , cobalt , cycloaddition , catalysis , selectivity , intermolecular force , chemistry , propane , transformation (genetics) , atom (system on chip) , combinatorial chemistry , organic chemistry , ring (chemistry) , molecule , computer science , parallel computing , biochemistry , gene
Three's a charm, but four's not half bad either : A simple cobalt–diphosphine complex facilitates the synthesis of cyclobutene derivatives through the chemoselective transformation of strained five‐membered unsaturated rings with internal alkynes (see scheme). This atom‐efficient, intermolecular reaction generates polycyclic products in excellent yields and with excellent exo selectivity. dppp=1,3‐bis(diphenylphosphanyl)propane.