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A Short Route to α‐Tocopherol
Author(s) -
Liu Kegang,
Chougnet Antoinette,
Woggon WolfD.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801765
Subject(s) - domino , aldol reaction , simple (philosophy) , derivative (finance) , key (lock) , computer science , content (measure theory) , tocopherol , chemistry , organic chemistry , philosophy , mathematics , computer security , epistemology , economics , vitamin e , mathematical analysis , financial economics , antioxidant , catalysis
Short and sweet : A simple and practical route to α‐tocopherol is described (see scheme; TES=triethylsilyl). The key step is a remarkably diastereoselective domino aldol/oxa‐Michael reaction, which is promoted by proline derivative 1 .