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Parallel Synthesis and Screening of Polymer‐Supported Phosphorus‐Stereogenic Aminophosphane–Phosphite and –Phosphinite Ligands
Author(s) -
den Heeten René,
Swennenhuis Bert H. G.,
van Leeuwen Piet W. N. M.,
de Vries Johannes G.,
Kamer Paul C. J.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801689
Subject(s) - phosphinite , stereocenter , phosphorus , chemistry , scheme (mathematics) , catalysis , combinatorial chemistry , stereochemistry , computer science , organic chemistry , mathematics , mathematical analysis , enantioselective synthesis
Bound to Ps : An efficient, rapid, parallel solid‐phase synthesis of a series of resin‐bound P‐stereogenic aminophosphane–phosphinite and –phosphite ligands is developed (see scheme). The ligands form active hydrogenation catalysts, displaying moderate to good enantioselectivities.