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Hybrid αγ Polypeptides: Structural Characterization of a C 12 /C 10 Helix with Alternating Hydrogen‐Bond Polarity
Author(s) -
Vasudev Prema G.,
Chatterjee Sunanda,
Ananda Kuppanna,
Shamala Narayanaswamy,
Balaram Padmanabhan
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801665
Subject(s) - hydrogen bond , chemistry , crystal structure , polarity (international relations) , helix (gastropod) , stereochemistry , crystallography , collagen helix , amino acid , peptide , triple helix , molecule , organic chemistry , biochemistry , ecology , biology , snail , cell
A different twist : A mixed C 12 /C 10 helix with alternating hydrogen‐bond directionality has been observed in the crystal structure of the hybrid αγ peptide Boc‐Leu‐Gpn‐Leu‐Aib‐OMe (see structure; Boc: tert ‐butoxycarbonyl; Leu: leucine; Gpn: 1‐(aminomethyl)cyclohexaneacetic acid (gabapentin); Aib: aminoisobutyric acid). The structure may be generalized to a regular mixed helix.