Hybrid αγ Polypeptides: Structural Characterization of a C 12 /C 10  Helix with Alternating Hydrogen‐Bond Polarity | Zendy

Vasudev Prema G. | Zendy; Chatterjee Sunanda | Zendy; Ananda Kuppanna | Zendy; Shamala Narayanaswamy | Zendy; Balaram Padmanabhan | Zendy

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Hybrid αγ Polypeptides: Structural Characterization of a C 12 /C 10 Helix with Alternating Hydrogen‐Bond Polarity

Author(s) -

Vasudev Prema G.,

Chatterjee Sunanda,

Ananda Kuppanna,

Shamala Narayanaswamy,

Balaram Padmanabhan

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200801665

Subject(s) - hydrogen bond , chemistry , crystal structure , polarity (international relations) , helix (gastropod) , stereochemistry , crystallography , collagen helix , amino acid , peptide , triple helix , molecule , organic chemistry , biochemistry , ecology , biology , snail , cell

A different twist : A mixed C 12 /C 10 helix with alternating hydrogen‐bond directionality has been observed in the crystal structure of the hybrid αγ peptide Boc‐Leu‐Gpn‐Leu‐Aib‐OMe (see structure; Boc: tert ‐butoxycarbonyl; Leu: leucine; Gpn: 1‐(aminomethyl)cyclohexaneacetic acid (gabapentin); Aib: aminoisobutyric acid). The structure may be generalized to a regular mixed helix.

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