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Solid‐Phase Organic Synthesis in the Presence of Compressed Carbon Dioxide
Author(s) -
Stobrawe Annika,
Makarczyk Piotr,
Maillet Céline,
Muller JeanLuc,
Leitner Walter
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801653
Subject(s) - supercritical carbon dioxide , hydroformylation , reagent , supercritical fluid , carbon dioxide , phase (matter) , materials science , homogeneous , chemical engineering , solid state , organic synthesis , chemistry , organic chemistry , catalysis , thermodynamics , engineering , physics , rhodium
Under pressure : The mass‐transfer limitation in solid‐phase organic synthesis with pressurized gaseous reagents is overcome by using carbon dioxide in the homogeneous supercritical state (right) for hydroformylation or under expanded‐liquid conditions (left) for Pauson–Khand reactions. The use of standard high‐pressure vessels and commercially available receptacles for the compartmentalization of substrates enables straightforward parallelization.