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Combinatorial Synthesis of Peptide Arrays with a Laser Printer
Author(s) -
Stadler Volker,
Felgenhauer Thomas,
Beyer Mario,
Fernandez Simon,
Leibe Klaus,
Güttler Stefan,
Gröning Martin,
König Kai,
Torralba Gloria,
Hausmann Michael,
Lindenstruth Volker,
Nesterov Alexander,
Block Ines,
Pipkorn Rüdiger,
Poustka Annemarie,
Bischoff F. Ralf,
Breitling Frank
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801616
Subject(s) - schematic , representation (politics) , peptide , coupling (piping) , laser , combinatorial chemistry , layer (electronics) , resolution (logic) , amino acid , materials science , computer science , nanotechnology , chemistry , optics , programming language , physics , biochemistry , engineering , electronic engineering , composite material , politics , political science , law
Special delivery : The “freezing” of activated amino acid derivatives within solid particles enables a laser printer to deliver these “postal packages” to defined locations on a solid support with high resolution. Subsequent parallel coupling is initiated simply by melting a whole layer of 20 different amino acid particles (see schematic representation; Fmoc=9‐fluorenylmethoxycarbonyl).