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Antimicrobial Surfaces through Natural Product Hybrids
Author(s) -
Wach JeanYves,
Bonazzi Simone,
Gademann Karl
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801570
Subject(s) - antimicrobial , natural product , ethylene glycol , product (mathematics) , antibiotics , linker , chemistry , combinatorial chemistry , microbiology and biotechnology , nanotechnology , biology , materials science , computer science , stereochemistry , organic chemistry , mathematics , operating system , geometry
The power of two! A natural product hybrid (see structure) composed of a siderophore and an antibiotic separated by a poly(ethylene glycol) linker enables the preparation of antimicrobial and cell‐resistant surfaces by a simple dip‐and‐rinse procedure. The anachelin siderophore (left) binds strongly to TiO 2 surfaces, and vancomycin is responsible for antibiotic activity.