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Small‐Molecule Inhibitors of MicroRNA miR‐21 Function
Author(s) -
Gumireddy Kiranmai,
Young Douglas D.,
Xiong Xin,
Hogenesch John B.,
Huang Qihong,
Deiters Alexander
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801555
Subject(s) - microrna , function (biology) , schematic , representation (politics) , computational biology , small molecule , computer science , class (philosophy) , gene , biology , genetics , artificial intelligence , engineering , political science , electronic engineering , politics , law
Short, but significant , microRNAs (miRNAs) are an important class of gene regulators. Small‐molecule modifiers of miRNA function, such as 1 (see schematic representation), were identified in a cellular screen for miRNA‐pathway inhibitors. Such compounds are expected to be useful tools for the elucidation of detailed mechanisms of miRNA action and may serve as lead structures for the development of new therapeutic agents.