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Enantioselective CH Amination Using Cationic Ruthenium(II)–pybox Catalysts
Author(s) -
Milczek Erika,
Boudet Nadège,
Blakey Simon
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801445
Subject(s) - enantioselective synthesis , cationic polymerization , ruthenium , amination , allylic rearrangement , chemistry , catalysis , pyridine , ligand (biochemistry) , combinatorial chemistry , stereochemistry , organic chemistry , receptor , biochemistry
The whole “pybox” and dice : Highly enantioselective amination reactions of both allylic and benzylic CH bonds are catalyzed by cationic ruthenium(II)–pybox complexes (see structure). A novel mode of stereocontrol, which is induced by the versatile pybox ligand, is proposed to account for the excellent enantioselectivity in these reactions. Boc= tert ‐butoxycarbonyl, pybox=pyridine bisoxazoline.