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Palladium‐Catalyzed Oxidative Cyclization of Enynes with Hydrogen Peroxide as the Oxidant
Author(s) -
Yin Guoyin,
Liu Guosheng
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801438
Subject(s) - hydrogen peroxide , catalysis , catalytic cycle , chemistry , palladium , oxidative phosphorylation , combinatorial chemistry , reductive elimination , peroxide , hydrogen bond , molecule , organic chemistry , biochemistry
Gently does it : The Pd‐catalyzed oxidative cyclization of enynes with hydrogen peroxide, a simple, inexpensive, and environmental benign oxidant, is proposed to proceed through a catalytic Pd II /Pd IV cycle in which the key CCl bond‐forming step is the formation of a Pd IV intermediate (see scheme). This is followed by a direct reductive elimination to generate CCl bonds with retention of the configuration of the C(sp 3 ) center.
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