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Catalytic Enantioselective Alkylation of Substituted Dioxanone Enol Ethers: Ready Access to C(α)‐Tetrasubstituted Hydroxyketones, Acids, and Esters
Author(s) -
Seto Masaki,
Roizen Jennifer L.,
Stoltz Brian M.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801424
Subject(s) - enantioselective synthesis , alkylation , enol , stereocenter , catalysis , chemistry , organic chemistry , combinatorial chemistry
Adaptive Alkylation : Palladium‐catalyzed asymmetric alkylation enables access to fully substituted enantioenriched oxygenated stereocenters, which can be transformed easily to α‐hydroxyketones, esters, and acids, providing a catalytic, enantioselective synthesis for natural products.