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Functionalizing Glycine Derivatives by Direct CC Bond Formation
Author(s) -
Zhao Liang,
Li ChaoJun
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801367
Subject(s) - glycine , chemistry , malonate , alkyne , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , amino acid , catalysis
Come on glycine : Two different types of glycine derivatives are α‐functionalized using cross‐dehydrogenative‐coupling (CDC) reactions. The method allows the efficient attachment of a malonate or aromatic alkyne group on the α‐position of the glycine derivatives under very mild conditions.