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Modular Chemoenzymatic One‐Pot Syntheses in Aqueous Media: Combination of a Palladium‐Catalyzed Cross‐Coupling with an Asymmetric Biotransformation
Author(s) -
Burda Edyta,
Hummel Werner,
Gröger Harald
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801341
Subject(s) - palladium , biotransformation , enantioselective synthesis , aqueous medium , catalysis , chemistry , alcohol dehydrogenase , combinatorial chemistry , organic chemistry , alcohol , coupling (piping) , enzyme , stereochemistry , aqueous solution , materials science , metallurgy
Two breeds of cat : A palladium‐catalyzed Suzuki cross‐coupling and an enzymatic reduction with an alcohol dehydrogenase from Rhodococcus sp. together enable the efficient and highly enantioselective synthesis of chiral biaryl alcohols in a one‐pot process (see scheme).