Modular Chemoenzymatic One‐Pot Syntheses in Aqueous Media: Combination of a Palladium‐Catalyzed Cross‐Coupling with an Asymmetric Biotransformation | Zendy

Burda Edyta | Zendy; Hummel Werner | Zendy; Gröger Harald | Zendy

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Modular Chemoenzymatic One‐Pot Syntheses in Aqueous Media: Combination of a Palladium‐Catalyzed Cross‐Coupling with an Asymmetric Biotransformation

Author(s) -

Burda Edyta,

Hummel Werner,

Gröger Harald

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200801341

Subject(s) - palladium , biotransformation , enantioselective synthesis , aqueous medium , catalysis , chemistry , alcohol dehydrogenase , combinatorial chemistry , organic chemistry , alcohol , coupling (piping) , enzyme , stereochemistry , aqueous solution , materials science , metallurgy

Two breeds of cat : A palladium‐catalyzed Suzuki cross‐coupling and an enzymatic reduction with an alcohol dehydrogenase from Rhodococcus sp. together enable the efficient and highly enantioselective synthesis of chiral biaryl alcohols in a one‐pot process (see scheme).

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