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NO Dismutase Activity of Seven‐Coordinate Manganese(II) Pentaazamacrocyclic Complexes
Author(s) -
Filipović Miloš R.,
Duerr Katharina,
Mojović Miloš,
Simeunović Vladica,
Zimmermann Robert,
Niketić Vesna,
IvanovićBurmazović Ivana
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801325
Subject(s) - disproportionation , chemistry , superoxide dismutase , manganese , redox , reactivity (psychology) , dismutase , metal , adduct , stereochemistry , enzyme , biochemistry , inorganic chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
Redox selectivity? Seven‐coordinate manganese(II) pentaazamacrocyclic complexes stimulate NO disproportionation by a novel dismutation mechanism based on the formation of labile metal–nitrosyl adducts and which is associated with the Mn II /Mn III redox cycle. The metal‐bound NO in these aducts has the character and reactivity of NO − and NO + species. Ex vivo studies suggest that superoxide dismutase mimics of this kind could interfere with NO‐mediated processes in biological milieu.