Premium
Nanohybrid Carbon Film for Electrochemical Detection of SNPs without Hybridization or Labeling
Author(s) -
Kato Dai,
Sekioka Naoyuki,
Ueda Akio,
Kurita Ryoji,
Hirono Shigeru,
Suzuki Koji,
Niwa Osamu
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801304
Subject(s) - electrochemistry , oligonucleotide , electrode , single nucleotide polymorphism , base (topology) , dna , glassy carbon , nucleotide , carbon fibers , materials science , chemistry , combinatorial chemistry , analytical chemistry (journal) , nanotechnology , gene , biochemistry , chromatography , genotype , mathematics , mathematical analysis , cyclic voltammetry , composite material , composite number
Base discrimination : A nanocarbon film electrode exhibits sufficiently high activity to obtain sharp, quantitative peaks for all the bases in an oligonucleotide. This property allows the label‐free electrochemical analysis of single‐nucleotide polymorphisms (SNPs) through the discrimination of single‐base differences solely by using electrochemical oxidation (see picture; ssDNA=single‐strand DNA).