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Macrocyclic Hexaoxazoles as Sequence‐ and Mode‐Selective G‐Quadruplex Binders
Author(s) -
Tera Masayuki,
Ishizuka Hiromichi,
Takagi Motoki,
Suganuma Masami,
Shinya Kazuo,
Nagasawa Kazuo
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801235
Subject(s) - antiparallel (mathematics) , g quadruplex , sequence (biology) , cationic polymerization , dna , combinatorial chemistry , chemistry , telomerase , stereochemistry , computational biology , biochemistry , computer science , microbiology and biotechnology , biology , gene , physics , organic chemistry , quantum mechanics , magnetic field
In a bind : Macrocyclic hexaoxazole G‐quadruplex binders with cationic side chains have been synthesized that are selective for the telo24 DNA sequence, and strongly stabilize telo24 in the antiparallel form (see picture). These compounds also showed potent telomerase‐inhibitory activity in both cell‐free and cell‐based assay systems.