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Organocatalytic Reactions with Acetaldehyde
Author(s) -
Alcaide Benito,
Almendros Pedro
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801231
Subject(s) - iminium , enamine , acetaldehyde , electrophile , organocatalysis , chemistry , catalysis , adduct , molecule , chirality (physics) , combinatorial chemistry , organic chemistry , enantioselective synthesis , physics , chiral symmetry breaking , ethanol , quantum mechanics , quark , nambu–jona lasinio model
Big step, small molecule : Although acetaldehyde is the simplest of enolizable carbonyl compounds, and low‐molecular‐weight enamine/iminium‐ion organocatalysis is the more elegant and most economical way to introduce chirality into a molecule, the first reports of the direct catalytic asymmetric reactions of acetaldehyde with electrophiles have just recently appeared (see scheme; Boc= tert ‐butyloxycarbonyl). Elaboration of the obtained adducts provides precursors for the synthesis of pharmaceuticals.