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Cage Escape Competes with Geminate Recombination during Alkane Hydroxylation by the Diiron Oxygenase AlkB
Author(s) -
Austin Rachel N.,
Luddy Kate,
Erickson Karla,
PenderCudlip Marilla,
Bertrand Erin,
Deng Dayi,
Buzdygon Ryan S.,
van Beilen Jan B.,
Groves John T.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801184
Subject(s) - alkb , chemistry , hydroxylation , cage , alkane , photochemistry , kinetics , cage effect , substrate (aquarium) , oxygenase , stereochemistry , biochemistry , hydrocarbon , organic chemistry , gene , biology , photodissociation , enzyme , ecology , physics , mathematics , combinatorics , quantum mechanics , dna repair
AlkB stops the radical clock : Three structurally analogous radical‐clock substrates with a large span in their rearrangement rates are hydroxylated by AlkB to afford similar amounts of rearranged ( 2 ) and unrearranged products ( 1 ). Such a result is in accord with radical rebound competing with cage escape of the geminate substrate radical. The results show that radical clocks can measure both the radical lifetime and the kinetics of cage escape.