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Direct Catalytic Asymmetric Three‐Component Kabachnik–Fields Reaction
Author(s) -
Cheng Xu,
Goddard Richard,
Buth Gernot,
List Benjamin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801173
Subject(s) - chemistry , catalysis , phosphoric acid , amino acid , component (thermodynamics) , combinatorial chemistry , protease , organic chemistry , organocatalysis , enantioselective synthesis , biochemistry , enzyme , physics , thermodynamics
As mimics of α‐amino acids , α‐amino phosphonates have great promise as antibacterial and anti‐HIV agents as well as protease inhibitors. Racemic α‐branched aldehydes react, in the presence the new chiral phosphoric acid catalyst 1 , directly with p ‐anisidine (PMPNH 2 ) and a phosphite to furnish β‐branched α‐amino phosphonates highly diastereoselectively and enantioselectively. Anth=anthracenyl.
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