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Self‐Assembly of Fibers and Nanorings from Disulfide‐Linked Helix–Loop–Helix Polypeptides
Author(s) -
Aili Daniel,
Tai FengI,
Enander Karin,
Baltzer Lars,
Liedberg Bo
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801155
Subject(s) - helix (gastropod) , disulfide bond , folding (dsp implementation) , triple helix , crystallography , loop (graph theory) , chemistry , nanotechnology , materials science , stereochemistry , biochemistry , biology , combinatorics , engineering , mathematics , mechanical engineering , ecology , snail
Joining the fold : Micrometer‐long and nanometer‐thin fibers of four‐helix bundles are formed by the folding‐mediated assembly of disulfide‐linked helix–loop–helix polypeptides (see picture). Fibers form both as a result of heteroassociation at neutral pH and homoassociation at acidic pH values. The heteroassociated fibers also assemble into nanorings with a diameter up to 5 μm.