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Asymmetric Catalysis Using Air: Clean Kinetic Resolution of Secondary Alcohols
Author(s) -
Wills Martin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801152
Subject(s) - kinetic resolution , enantioselective synthesis , iridium , catalysis , chemistry , kinetic energy , combinatorial chemistry , resolution (logic) , organic chemistry , computer science , physics , quantum mechanics , artificial intelligence
An air of excitement : Enantioselective catalysts have been developed for the kinetic resolution of racemic alcohols using aerobic oxidation. The iridium(III) complex shown (Ms=methanesulfonyl), which was developed by Ikariya et al., proved to be particularly efficient. Besides several other examples, the aspects of the mechanism are discussed.