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Chiral Bis(pyridylimino)isoindoles: A Highly Modular Class of Pincer Ligands for Enantioselective Catalysis
Author(s) -
Langlotz Björn K.,
Wadepohl Hubert,
Gade Lutz H.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801150
Subject(s) - hydrosilylation , cyclopropanation , pincer movement , enantioselective synthesis , cobalt , chemistry , catalysis , combinatorial chemistry , modular design , isoindole , organic chemistry , computer science , operating system
Protect your back : Chiral wedges (red, see scheme) at the wingtips of bis(2‐pyridylimino)isoindole (bpi) pincer ligands with an appropriate protective hedge (green), to block the metal center from backside attack, in the backbone represent a new class of efficient 3d‐metal catalysts. These catalysts gave excellent enantioselectivities in the iron‐catalyzed hydrosilylation of arylketones and in the cobalt‐catalyzed cyclopropanation of alkenes.