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Amphiphilic/Bipolar Metallocorroles That Catalyze the Decomposition of Reactive Oxygen and Nitrogen Species, Rescue Lipoproteins from Oxidative Damage, and Attenuate Atherosclerosis in Mice
Author(s) -
Haber Adi,
Mahammed Atif,
Fuhrman Bianca,
Volkova Nina,
Coleman Raymond,
Hayek Tony,
Aviram Michael,
Gross Zeev
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801149
Subject(s) - decomposition , oxidative phosphorylation , chemistry , reactive oxygen species , biochemistry , catalysis , nitrogen , oxygen , cholesterol , lipoprotein , organic chemistry
Antioxidants that work! The iron corrole 1‐Fe (see picture) is a potent catalyst for decomposition of reactive oxygen and nitrogen species that binds selectively to lipoproteins. The complex also affects cholesterol levels and its cellular efflux. 1‐Fe is more effective than natural antioxidants in reducing atherosclerosis development in mice. LDL=low‐density lipoprotein.