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Contact Ion Pair Directed Lewis Acid Catalysis: Asymmetric Synthesis of trans ‐Configured β‐Lactones
Author(s) -
Kull Thomas,
Peters René
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801143
Subject(s) - catalysis , lewis acids and bases , chemistry , stereoselectivity , halide , lewis acid catalysis , synergistic catalysis , ion , stereochemistry , combinatorial chemistry , organic chemistry
Opposites attract. A novel concept for dual‐activation catalysis takes advantage of the cooperative action of aprotic contact ion pair catalysis and Lewis acid catalysis. This strategy was used for the first trans ‐selective catalytic asymmetric [2+2] cyclocondensation of acyl halides with aliphatic aldehydes, furnishing trans ‐configured 3,4‐disubstituted β‐lactones with high stereoselectivity.