Enantioselective Synthesis of α‐Aryl Alkylamines by Rh‐Catalyzed Addition Reactions of Arylboronic Acids to Aliphatic Imines | Zendy

Trincado Mónica | Zendy; Ellman Jonathan A. | Zendy

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Enantioselective Synthesis of α‐Aryl Alkylamines by Rh‐Catalyzed Addition Reactions of Arylboronic Acids to Aliphatic Imines

Author(s) -

Trincado Mónica,

Ellman Jonathan A.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200801137

Subject(s) - enantioselective synthesis , chemistry , pyrrolidine , catalysis , aryl , rhodium , organic chemistry , medicinal chemistry , cyclooctene , alkyl

Aliphatic imines take center stage : The first enantioselective catalytic addition of arylboronic acids to branched and unbranched N ‐tosyl‐ and N ‐diphenylphosphinoyl aliphatic imines has been developed with selectivities of up to 98 % ee (see scheme; acac=acetylacetonate, coe=cyclooctene, ( R , R )‐deguphos=( R , R )‐1‐benzyl‐3,4‐bis(diphenylphosphino)pyrrolidine).

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