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Homogeneous Catalytic Hydroamination of Alkynes and Allenes with Ammonia
Author(s) -
Lavallo Vincent,
Frey Guido D.,
Donnadieu Bruno,
Soleilhavoup Michele,
Bertrand Guy
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801136
Subject(s) - hydroamination , cationic polymerization , catalysis , chemistry , carbene , homogeneous , ammonia , organic chemistry , alkyl , homogeneous catalysis , combinatorial chemistry , medicinal chemistry , physics , thermodynamics
A golden ticket to the synthesis of reactive nitrogen‐containing compounds, such as imines, enamines, and allyl amines, through the addition of NH 3 to unsaturated bonds is the cationic cyclic (alkyl)(amino)carbene–gold(I) catalyst shown in blue (Dipp=diisopropylphenyl). An ideal initial step for the preparation of simple bulk chemicals, this reaction is also useful for the synthesis of more complex molecules (see examples).